2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Names and Identifiers

Name	2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid
Synonyms	GW501516 GW 501516 CB6465728 GW-501615 GW-501516 Cardarine(GW501516, GSK-516) 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid {2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-acetic acid Acetic acid, (2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)- 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid {2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
CAS	317318-70-0
EINECS	1592732-453-0
InChI	InChI=1/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
InChIKey	YDBLKRPLXZNVNB-UHFFFAOYSA-N

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Physico-chemical Properties

Molecular Formula	C21H18F3NO3S2
Molar Mass	453.5
Density	1.42±0.1 g/cm3(Predicted)
Melting Point	134-136°C
Boling Point	584.5±60.0 °C(Predicted)
Flash Point	307.321°C
Solubility	DMSO: soluble20mg/mL, clear
Vapor Presure	0mmHg at 25°C
Appearance	powder
Color	white to beige
BRN	18515150
pKa	3.17±0.10(Predicted)
Storage Condition	-20°C
Stability	Light Sensitive
Refractive Index	1.619
In vitro study	GW 501516 is shown to be the most potent and selective PPARα agonists known with an EC 50 of 1.1 nM against PPARα and 1000-fold selectivity over the other human subtypes, PPARα and-γ. GW 501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx) cells. GW 501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner.
In vivo study	GW 501516 causes impaired bone formation, leading to decreased BMD and deterioration of bone properties in OVX rats. GW 501516 attenuates interstitial inflammation and proximal tubular cell damage in a protein-overload mouse nephropathy model. GW 501516 treatment enhances running endurance and the proportion of succinate dehydrogenase (SDH)-positive muscle fibres in both trained and untrained mice.

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Risk and Safety

WGK Germany	3
RTECS	AI9105500

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Reference Information

biological activity	GW 501516 (GW 1516) is an agonist of PPARδ with an EC50 value of 1.1 nM.
Target	Value
PPARδ (Cell-free assay)	1 nM(Ki)

Last Update：2024-04-09 21:01:54

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a

Hubei YoungXin Pharmaceutical Tech Co.,Ltd.

Spot supply

Product Name: GW 501516 Visit Supplier Webpage Request for quotation
CAS: 317318-70-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Shanghai Worldyang Chemical Co.,Ltd.

Product Name: GW 501516 Request for quotation
CAS: 317318-70-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228

Wechat: 13651600618
WhatsApp: +8613651600618

Hubei YoungXin Pharmaceutical Tech Co.,Ltd.

Spot supply

Product Name: GW 501516 Visit Supplier Webpage Request for quotation
CAS: 317318-70-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Shanghai Worldyang Chemical Co.,Ltd.

Product Name: GW 501516 Request for quotation
CAS: 317318-70-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228

Wechat: 13651600618
WhatsApp: +8613651600618

View History

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a
1,3-Dioxane-2-carboxaldehyde, 4-(methoxymethyl)- (9CI)
1,5-二氯戊烷
PHTHALIMIDOPEROXYCAPROIC ACID
174689-92-0

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a

2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid

CAS: 317318-70-0

Molecular Formula: C21H18F3NO3S2

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Names and Identifiers

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Physico-chemical Properties

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Risk and Safety

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Reference Information

Supplier List

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a Request for Quotation

2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid

CAS: 317318-70-0

Molecular Formula: C21H18F3NO3S2

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Names and Identifiers

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Physico-chemical Properties

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Risk and Safety

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a - Reference Information

Supplier List

2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a